Penelope Brock Selected Research

Hepatoblastoma

1/2019	Microscopically positive resection margin after hepatoblastoma resection: what is the impact on prognosis? A Childhood Liver Tumours Strategy Group (SIOPEL) report.
4/2016	Adaptive dosing of anticancer drugs in neonates: facilitating evidence-based dosing regimens.
8/2013	Dose-dense cisplatin-based chemotherapy and surgery for children with high-risk hepatoblastoma (SIOPEL-4): a prospective, single-arm, feasibility study.
12/2012	Efficacy of irinotecan single drug treatment in children with refractory or recurrent hepatoblastoma--a phase II trial of the childhood liver tumour strategy group (SIOPEL).
10/2012	Docetaxel in the treatment of children with refractory or relapsed hepatoblastoma.
7/2012	Prognostic stratification for children with hepatoblastoma: the SIOPEL experience.
5/2010	Successful treatment of childhood high-risk hepatoblastoma with dose-intensive multiagent chemotherapy and surgery: final results of the SIOPEL-3HR study.
10/2009	Cisplatin versus cisplatin plus doxorubicin for standard-risk hepatoblastoma.
3/2008	Hepatoblastoma with a low serum alpha-fetoprotein level at diagnosis: the SIOPEL group experience.
10/2004	Phase II study of high-dose cyclophosphamide in relapsing and/or resistant hepatoblastoma in children: a study from the SIOPEL group.

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Penelope Brock Research Topics

Disease

10	Neuroblastoma 01/2020 - 07/2010
10	Hepatoblastoma 01/2019 - 10/2004
7	Neoplasms (Cancer) 11/2020 - 10/2009
4	Infections 12/2018 - 12/2006
4	Neoplasm Metastasis (Metastasis) 01/2018 - 05/2010
2	Hearing Loss (Hearing Impairment) 11/2020 - 01/2019
2	Ototoxicity 01/2019 - 01/2017
2	Fever (Fevers) 12/2018 - 07/2010
2	Pain (Aches) 12/2018 - 01/2018
1	Margins of Excision 01/2019
1	Hypersensitivity (Allergy) 12/2018
1	Pulmonary Hypertension 12/2018
1	Heart Failure 12/2018
1	Mycoses (Diseases, Fungus) 12/2018
1	Capillary Leak Syndrome 12/2018
1	Respiratory Distress Syndrome (Acute Respiratory Distress Syndrome) 12/2018
1	Pulmonary Fibrosis (Fibrosing Alveolitis) 12/2018
1	Bone Marrow Diseases (Bone Marrow Disease) 01/2018
1	Sexually Transmitted Diseases (Sexually Transmitted Disease) 01/2018
1	Stomatitis 01/2017
1	Body Weight (Weight, Body) 04/2016
1	Pathologic Complete Response 08/2013
1	Rupture 08/2013
1	Febrile Neutropenia 07/2010
1	Opportunistic Infections (Opportunistic Infection) 12/2006
1	Lymphoma (Lymphomas) 12/2006

Drug/Important Bio-Agent (IBA)

8	Cisplatin (Platino)FDA LinkGeneric 11/2020 - 10/2009
4	Doxorubicin (Adriamycin)FDA LinkGeneric 01/2018 - 10/2009
4	Pharmaceutical PreparationsIBA 01/2017 - 10/2012
4	Carboplatin (JM8)FDA LinkGeneric 01/2017 - 05/2010
3	dinutuximabIBA 01/2020 - 01/2018
3	Vincristine (Oncovin)FDA LinkGeneric 01/2018 - 07/2010
3	Etoposide (VP 16)FDA LinkGeneric 01/2017 - 07/2010
3	Cyclophosphamide (Cytoxan)FDA LinkGeneric 01/2017 - 10/2004
3	alpha-Fetoproteins (alpha-Fetoprotein)IBA 05/2010 - 03/2008
2	Topotecan (Hycamtin)FDA LinkGeneric 01/2018 - 01/2017
2	3-Iodobenzylguanidine (Iobenguane)IBA 01/2018 - 08/2017
2	Biomarkers (Surrogate Marker)IBA 01/2017 - 04/2014
1	Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF)IBA 12/2018
1	Monoclonal AntibodiesIBA 12/2018
1	Interleukin-2 (IL2)IBA 12/2018
1	Morphine (MS Contin)FDA LinkGeneric 01/2018
1	CytokinesIBA 01/2018
1	IodineIBA 01/2018
1	Tretinoin (Retinoic Acid)FDA LinkGeneric 01/2018
1	Iodine-123IBA 08/2017
1	Fluorodeoxyglucose F18 (Fludeoxyglucose F 18)FDA Link 08/2017
1	thiopurine methyltransferase (thiopurine S-methyltransferase)IBA 01/2017
1	Mitogen-Activated Protein Kinase Kinases (MEKs)IBA 01/2017
1	Melphalan (Alkeran)FDA LinkGeneric 01/2017
1	Aurora KinasesIBA 01/2017
1	Checkpoint Kinase 1IBA 01/2017
1	Mechanistic Target of Rapamycin Complex 1IBA 01/2017
1	Catechol O-Methyltransferase (Methyltransferase, Catechol)IBA 01/2017
1	Busulfan (Busulfex)FDA Link 01/2017
1	RNA-Directed DNA Polymerase (Reverse Transcriptase)IBA 04/2014
1	Messenger RNA (mRNA)IBA 04/2014
1	Tyrosine 3-Monooxygenase (Tyrosine Hydroxylase)IBA 04/2014
1	Fetal Proteins (Fetoprotein)IBA 08/2013
1	Irinotecan (Camptosar)FDA LinkGeneric 12/2012
1	Docetaxel (Taxotere)FDA Link 10/2012
1	Granulocyte Colony-Stimulating Factor (G-CSF)IBA 07/2010
1	Filgrastim (Neupogen)FDA Link 07/2010
1	Anti-Bacterial Agents (Antibiotics)IBA 07/2010

Therapy/Procedure

8	Drug Therapy (Chemotherapy) 01/2019 - 12/2006
4	Therapeutics 01/2018 - 07/2012
3	Immunotherapy 01/2020 - 01/2018
2	Liver Transplantation 01/2018 - 05/2010
2	Hepatectomy 01/2018 - 05/2010
2	Radiotherapy 10/2012 - 12/2006
1	Aftercare (After-Treatment) 12/2018
1	Investigational Therapies (Experimental Therapy) 01/2017
1	Cranial Irradiation 12/2006